May 19, 2022
In patients with serious and long-term COVID-19, disturbed blood coagulation has often been observed. Now, researchers at Linköping University (LiU), Sweden, have discovered that the body’s immune system can affect the spike protein on the surface of the SARS-CoV-2 virus, leading to the production of a misfolded spike protein called amyloid. The discovery of a possible connection between harmful amyloid production and symptoms of COVID-19 has been published in the Journal of American Chemical Society.
In those who have serious and long-term COVID-19, organs other than the lungs can be gravely affected. Complex symptoms and damage in, for example, the heart, kidneys, eyes, nose, and brain, as well as disturbed blood coagulation, can persist. Why the illness affects the body in this way is largely a mystery. Now, researchers at LiU have found a biological mechanism which has never been described before, and which can be a part of the explanation.